Retinal regeneration in amphibians.
نویسنده
چکیده
This review is a comparative analysis of retina regeneration in different amphibians. Special attention is given to the newt, which, unlike other vertebrates, retains the capacity for the regeneration of eye structures for all life. The review focuses on the sources of the cells which contribute to retina regeneration, proliferative activity of cells participating in regeneration, the factors which control the process, and the genes expressed during the course of regeneration.
منابع مشابه
Hematological- and Neurological-Expressed Sequence 1 Gene Products in Progenitor Cells during Newt Retinal Development
Urodele amphibians such as Japanese common newts have a remarkable ability to regenerate their injured neural retina, even as adults. We found that hematological- and neurological-expressed sequence 1 (Hn1) gene was induced in depigmented retinal pigment epithelial (RPE) cells, and its expression was maintained at later stages of newt retinal regeneration. In this study, we investigated the dis...
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In urodele amphibians like the newt, complete retina and lens regeneration occurs throughout their lives. In contrast, anuran amphibians retain this capacity only in the larval stage and quickly lose it during metamorphosis. It is believed that they are unable to regenerate these tissues after metamorphosis. However, contrary to this generally accepted notion, here we report that both the neura...
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PURPOSE OF REVIEW Retinal degenerative diseases have immense socio-economic impact. Studying animal models that recapitulate human eye pathologies aids in understanding the pathogenesis of diseases and allows for the discovery of novel therapeutic strategies. Some non-mammalian species are known to have remarkable regenerative abilities and may provide the basis to develop strategies to stimula...
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Amphibian retinal regeneration has been intensely studied, using the urodele as a model organism. Transdifferentiation of retinal pigment epithelium (RPE) into retinal stem cells play a crucial role in regeneration. Recently, it was found that anurans (Xenopus laevis) in the adult stage also can regenerate the retina similarly to the newt. This provides a new tool of a model for the molecular m...
متن کاملRegeneration of the amphibian retina: role of tissue interaction and related signaling molecules on RPE transdifferentiation.
Regeneration of eye tissue is one of the classic subjects in developmental biology and it is now being vigorously studied to reveal the cellular and molecular mechanisms involved. Although many experimental animal models have been studied, there may be a common basic mechanism that governs retinal regeneration. This can also control ocular development, suggesting the existence of a common princ...
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عنوان ژورنال:
- The International journal of developmental biology
دوره 41 6 شماره
صفحات -
تاریخ انتشار 1997